The in vitro interactions between antibiotics(ampicillin, kanamycin, cephalexin, oxytetracycline and chloramphenicol) and ginseng saponin were studied by the chessboard method against bacteria(Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Mycobacterium smegmatis).
Ampicillin, kanamycin, oxytetracycline and chloramphenicol against Bacillus subtilis, and ampicillin and cephalexin against Staphylococcus aureus were synergistic in the presence of ginseng saponin. Whereas kanamycin, oxytetracycline and chloramphenicol against Staphylococcus aureus, and ampicillin, Kanamycin, cephalexin, oxytetracycline and chlorampheniol against Escherichia coli, and ampicillin, kanamycin, and chloramphenicol against Pseudomonas aeruginosa, and ampicillin and chloramphenicol against Mycobacterium smegmatis were indifferent in the presence of ginseng saponin. Antagonisms between antibiotics and ginseng saponin were not observed in this study.
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